L–Citrulline is an amino acid that has been found to play an important role in nitric oxide (NO) metabolism and regulation. L-Citrulline is converted to L-Arginine in the body, leading to increases in both L-Arginine and nitric oxide. Increased production of nitric oxide promotes vascular dilation, which helps support normal oxygen and blood circulation throughout the body.
The pharmacokinetic advantage of L-Citrulline is that it is not subject to any elimination by the liver prior to entering the bloodstream. Conversely, L-Arginine is subject to extensive elimination by the gut wall and liver. (26)
The majority of L-Citrulline is converted to L-Arginine in the kidney. (3)
Once in circulation, L-Arginine is readily converted into L-Citrulline and nitric oxide, which in turn serves as an L-Arginine precursor (see figure below). (10)
CONVERSION FROM ARG (L-ARGININE) TO CIT
ABSORPTION OF L-ARGININE AND L-CITRULLINE
*CIT INGESTION ENABLES EFFECTIVE SUPPLY OF ARG TO THE WHOLE BODY
ROLES OF CIT
IN THE BODY
- Influences on blood vessels: Actions via NO production, vasodilation, blood flow acceleration
- Ammonia detoxification: Action as a component of the L-ornithine cycle
- Antioxidant effect: An active oxygen radical scavenger (potent quencher of hydroxyl radical)
* Citrulline Malate is mixed 1:1 (Malic Acid + L-Citrulline). Basically, the L-Citrulline is cut in half!
** Most brands use Citrulline Malate 1:1 ratio due to cost (cheap) – 50% less per kg than pure L-Citrulline.
KAGED MUSCLE L-CITRULLINE
- FERMENTATION DERIVED VS. SYNTHETIC
- GRAS APPROVED
- ONLY CITRULLINE ACTUALLY MANUFACTURED IN THE USA (NOT OVERSEAS)
DARE TO COMPARE
OUR L-CITRULLINE TO THE COMPETITION